Laboratory for extraction of natural products and synthesis of bioactive compounds

The BioPharm Lab Complex includes three well integrated laboratories and a supporting analytical center: — Laboratory for extraction of natural products and synthesis of bioactive compounds; — “In vitro” laboratory for evaluation of biological activity and toxicity; — Pharmaceutical development and characterization and “In Silico“ design. The lab complex is designed to perform problem-driven and industry oriented R&D directed to efficient, value-added and environmentally-friendly utilization of the national bio-resources and valorization of industry byproducts and bio-wastes to obtain products with high added value.

    • Application of green extraction technologies for utilization of Medicinal Aromatic Plants (MAPs).
    • Fractioning and purification of extracts, investigation of the content of active ingredients and their biological activity.
    • Determination of activity profiles and development of standard procedures and documentation for phytochemical production, oriented to small and medium sized enterprises (SMEs).
    • Development of standardization and control procedures for MAPs-based products, with the purpose to guarantee the consumer’s interests.
    • Isolation of individual biologically active compounds, structure elucidation and synthesis of natural compounds analogues, possessing structural diversity and bioactivity (identification of promising compounds for development of drug candidates).

Current projects:

– Development of a method for quantitative determination of pyrrolizidine alkaloids in dry plant material (herbs)

– Characterization and standardization of the various types of essential oil of Melissa officinalis (Lemon Balm oil);

– Development of new approaches for verifying the authenticity of Rose and Lavender oils;

– Development of methods for monitoring of natural products by high performance thin layer chromatography (HPTLC);

– Development of a method for the determination of allergens in essential oils and cosmetic formulations.

Completed projects:

Preparation of bioactive extracts from medicinal plants for the creation of innovative products

Services
  • Development of procedures for extraction of biologically active components from medicinal plants. Preparation of pilot quantities of standardized bioactive extracts accompanied by analytical and others protocols
  • Development of methods for analysis of mixtures of natural compounds, components for incorporation in cosmetic products, and final pharmaceutical formulations.
  • Development of methodologies for analysis of natural products by high-performance thin-layer chromatography (HPTLC).
  • Development of methods and procedures for synthesis, as well as obtaining of specified quantities of organic compounds ordered by pharmaceutical companies.
  • Development of methods for the control of compounds in plant extracts (eg caffeic acid, rosmarinic acid, quercetin, etc.);
  • Authentication of rose oil by GC-MS analysis.
Equipment
  • GC with QTOF MS / MS detector
  • GC with FID and MS detectors
  • Triple Quadrupole Mass Spectrometer – LCMS-8045
  • Liquid Chromatograph with Diode Array Detector and Single Quadrupole Mass Spectrometer – LCMS-2020
  • Liquid Chromatograph with Diode Array Detector and Fluorescence Detector – Nexera X2.
  • Apparatuses for automatic application, development, functionalization and densitometry of TLC / HPTLC plates;
  • Flash chromatographs;
  • Multi-purpose 5 liter reactor;
  • Laboratory equipment for extraction of natural products and synthesis of organic compounds (reactors, rotary vacuum evaporators, vacuum installations, etc.)
bioinfotech-director
Prof. Vladimir Dimitrov
Management

Dissertation (Dr. rer. Nat.) at the Technical University of Leuna-Merseburg; 2002 “Doctor of chemical sciences” HAC; 1989-1990 Scholarship Foundation Alexander von Humboldt; 1992 and 1998-2001 researcher at the University of Zurich;

Numerous lectures at foreign universities and international conferences; Numerous articles in international journals;

Many completed contracts in the EU framework programs, international funds, etc; contracts with pharmaceutical companies. Contracts in the EU framework programs, international funds, etc .; contracts with pharmaceutical companies.

 

Sofia, bul. Tsarigradsko Shousse 111

Laboratory Complex, Floor 2

e-mail:synthesys-lab@sofiatech.bg

labs@sofiatech.bg

Phone: + 359 0889 900 614

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